Albert Einstein College of Medicine



Quezada A, Ward C, Bader E, Zolotavin P, Altun E, Hong S, Killian N, Xie C, Batista-Brito R, Hébert JM. An in vivo platform for rebuilding functional neocortical tissue. Bioengineering, in press.


Krzyspiak J, Khodakhah K, Hébert JM. Potential variables for improved reproducibility of neuronal cell grafts at stroke sites. Cells 11: 1656. PMID 356266993

Hébert JM. Could an old brain be made young again? Surgical Neurology International. 13:1-5. PMID 36600738


Hébert JM. (2021). Is life-extension research on the wrong track? Rejuvenation Research 24:375–376. PMID: 34405690.

Krzyspiak J, Yan J, Ghosh HS, Galinski B, Lituma P, Alvina K, Quezada A, Kee S, Grońska-Pęski M, Tai YD, McDermott K, Gonçalves JT, Zukin RS, Weiser DA, Castillo P, Khodakhah K, Hébert JM. (2021). Donor-derived vasculature is required to support neocortical cell grafts after stroke. Stem Cell Research 59:102642. PMID: 34971934

Galinski B, Luxemburg M, Landesman Y, Pawel B, Master SR, Freeman K, Hébert JM, Weiser D. (2021). IkB modulates synergy between selinexor, an XPO1 inhibitor, and bortezomib in neuroblastoma. Translational Oncology 14:101114. PMID: 33975179

Shariq M, Sahasrabuddhe V, Krishna S, Radha S, Nruthyathi, Bellampalli R, Dwivedi A, Cheramangalam R, Reizis B, Hébert JM, Ghosh HS (2021). Adult neural stem cells have latent inflammatory potential that is kept in check by Tcf4 to facilitate neurogenesis. Science Advances 7:eabf5606. PMID: 34020954

Gronska-Peski M, Gonçalves JT, Hébert JM (2021). Enriched environment acts through FGFRs to increase adult hippocampal neurogenesis. J. Neuroscience 41: 2899-2910. PMID: 33637561

Gronska-Peski M, Mowrey W, Hébert JM. (2021). FGFR regulation of dendrite elaboration in adult-born granule cells depends on intracellular mediator and proximity to the soma. Neuroscience 453:148-167. PMID 33246055


Gronska-Peski M, Schachner M, Hébert JM. L1cam curbs the differentiation of adult-born hippocampal neurons. Stem Cell Research 48:101999. PMID 32971459

Hébert JM. (2020). Replacing Aging. Science Unbound press, New York, New York.                   See also: de Grey ADNJ. (2020) Review of Replacing Aging by Jean M. Hébert. Rejuvenation Res. 23:541-542. PMID 33261523.

Blackwood CA, Bailetti A, Nandi S, Gridley T, Hébert JM. (2020). Notch dosage: Jagged1 haploinsufficiency is associated with reduced neuronal division and disruption of periglomerular interneurons in mice. Frontiers Cell Dev. Biol. 8:113. PMID 32161758. PMCID PMC7054221.

Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick J, Wang M, Kalpana K, Rose I, Burstein SR, Rusielewicz T, Nijsure M, Croft G, Zhang B, Nobuta H, Hébert JM, Liddelow S, Fossati V. (2020). CD49f is a novel marker of functional and reactive human iPSC-derived astrocytes. Neuron 107:436-453. PMID 32485136.

Tole S, Hébert JM. (2020). Telencephalic Patterning. In “Patterning and cell type specification in the developing CNS and PNS, Comprehensive Developmental Neuroscience”, Volume 1, Elsevier, 2nd ed. Rakic P, Rubenstein J. in press.


Hébert JM, Loring JF. (2019). Cell Replacement. In: Gu D, Dupre M (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham.

Kang W, Nguyen KCQ, Hébert JM. (2019). Transient redirection of SVZ-stem cells to oligodendrogenesis by FGFR activation promotes remyelination. Stem Cell Reports 12:1223–1231. PMID 31189094. PMCID PMC6565886.

Kamatkar N, Levy M, Hébert JM. (2019). Development of a monomeric inhibitory RNA aptamer specific for FGFR3 that acts as an activator when dimerized. Mol. Ther. Nuc. Acids 17:530–339. PMID 31357131. PMCID PMC6661505.

Furusho M, Ishii A, Hébert JM, Bansal R. (2019). Developmental stage-specific role of Frs adapters as mediators of FGF-Receptor signaling in the oligodendrocyte-lineage cells. Glia 68:617–630. PMID 31670856. PMCID pending.


Hébert JM, Vijg J. (2018). Cell replacement to reverse brain aging: challenges, pitfalls, and opportunities. Trends Neurosci. 41: 267–279. PMID: 29548515. PMCID: PMC5924639.

Nandi S, Alviña K, Lituma PJ, Castillo PE, Hébert JM. (2018). Neurotrophin and FGF signaling adapter proteins, FRS2 and FRS3 regulate dentate granule cell maturation and excitatory synaptogenesis. Neuroscience 369: 192–201. PMID: 29155277. PMCID: PMC5766409. Cover illustration.

Antoine MW, Zhu X, Dieterich M, Brandt T, Vijayakumar S, McKeehan N, Arezzo J, Zukin RS, Borkholder D, Jones SM, Frisina R, Hébert JM. (2018). Early uneven ear input induces long-lasting differences in left-right motor function. PLoS Biology 16: e2002988. PMID: 29534062. PMCID PMC5849283.


Antoine MW, Vijayakumar S, McKeehan N, Jones S, Hébert, JM. (2017). The severity of vestibular dysfunction in deafness as a determinant of comorbid hyperactivity or anxiety. J. Neurosci. 37: 5144–5154. PMID: 28438970. PMCID: PMC5444197.

Nandi S, Gutin G, Blackwood CA, Kamatkar NG, Lee KW, Fishell G, Wang F, Goldfarb M, Hébert JM. (2017). Context-driven, receptor-dependent usage of an intracellular adapter governs specificity in FGF signal transduction. J. Neurosci. 37:5690–5698. PMID: 28483978. PMCID: PMC5469306.

Andriani GA, Faggioli F, Baker D, Dollé MET, Sellers RS, Hébert JM, van Steeg H, Hoeijmakers J, Vijg J, Montagna C. (2016). Whole chromosome aneuploidy in the brain of BubR1H/H and Ercc1 -/Δ7 mice. Hum. Mol. Gen. 25: 755–765. PMID: 26681803. PMCID: PMC4743693.

Nandi S, Chandramohan D, Fioriti L, Melnick AM, Hébert JM, Mason CE, Kandel ER, Rajasethupathy P. (2016). A role for piRNAs in retrotransposon silencing in the mammalian brain. P.N.A.S. U.S.A. 113: 12696–12702. PMID: 27791114. PMCID: PMC5111663.


Kang W, Balordi F, Su N, Chen L, Fishell G, Hébert JM. (2014). Astrocyte activation is suppressed in both normal and injured brain by FGF signaling. PNAS 111: E2987–E2995. PMID: 25002516. PMCID: PMC4115557.


Hébert JM. (2013). Only scratching the cell surface; extracellular signals in cerebrum development. Curr. Opin. Genet. Dev. 23: 470–474. PMID: 23669550. PMCID: PMC3748208.

Tole S, Hébert JM. (2013). Telencephalic patterning. In “Patterning and cell type specification in the developing CNS and PNS, Comprehensive Developmental Neuroscience”, Volume 1, Elsevier, ed. Pasko Rakic and John Rubenstein. p. 3–24.

Diaz F*, McKeehan N*, Kang W, Hébert JM. (2013). Apoptosis of glutamatergic neurons fails to trigger a neurogenic response in the adult neocortex. J. Neurosci. 33: 6278–6284. PMID: 23575827. PMCID: PMC3644398. Featured article of the week.

Antoine M, Hübner CA, Arezzo JC, Hébert JM. (2013). A causative link between inner ear defects and long-term striatal dysfunction. Science 341: 1120–1123. PMID: 24009395. PMCID: PMC4731229. Highlighted in Cell’s Leading Edge.


Paek H, Antoine M, Diaz F, Hébert JM. (2012). Increased Β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. Dev. Dyn. 241: 242–246. PMID: 22102609, PMCID: PMC3266450.

Fernandes M, Antoine M, Hébert JM. (2012). SMAD4 is essential in generating rhombic lip-derived neurons during cerebellar development. Dev. Biol. 365: 82–90. PMID: 22370000. PMCID: PMC3322275.

Kang W, Hébert JM. (2012). A Sox2 BAC transgenic approach for targeting adult neural stem cells. PLoS ONE 7: e49038. PMID: 23145058. PMCID: PMC3492187.

Khonsari RH, Delezoide AL, Kang W, Hébert JM, Bessières B, Bodiguel V, Collet C, Legeai-Mallet L, Sharpe PT, Fallet-Bianco C. (2012). Central nervous system malformations and deformations in FGFR2-related craniosynostosis. Am. J. Med. Genet. PartA 158: 2797–2806. PMID 22987770.


Kang W, Hébert JM. (2011). Signaling pathways in reactive astrocytes, a genetic perspective. Mol. Neurobiol. 43: 147–154. PMID: 21234816, PMCID: PMC3087829.

Hébert JM. (2011). FGFs: neurodevelopment’s Jack-of-all-trades—how do they do it? Frontiers in Neurogenesis 5: 133. PMID: 22164131 PMCID: PMC3230033.

Furusho M, Kaga Y, Ishii A, Hébert JM, Bansal R. (2011). FGF signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain. J. Neurosci. 31: 5055–5066. PMID: 21451043, PMCID: PMC3086363.

Paek H, Hwang JY, Zukin RS, Hébert JM. (2011). β-catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4. Dev. Cell 20: 689–699. PMID: 21571225, PMCID: PMC3099549. “F1000, rating 6, recommended”

Ferretti E, Li B, Zewdu R, Wells V, Hébert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L. (2011). A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis. Dev. Cell 21: 627–641. PMID: 21982646, PMCID: PMC3199312. Highlighted in Science, Editors’ Choice, 2011, v.334:434. “F1000, rating 6, recommended”.


Maier E, von Hofsten J, Nord H, Fernandes M, Paek H, Hébert JM, Gunhaga L. (2010). Opposing activities of FGF and BMP regulate the olfactory sensory versus respiratory epithelial cell fate decision. Development 137: 1601–1611. PMID: 20392740, PMCID: PMC2860246. “F1000, rating 6, recommended”


Paek H, Gutin G, Hébert JM. (2009). FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development 136: 2457–2465. PMID: 19542358, PMCID: PMC2729352. “F1000, rating 8, must read”

Kang W, Wong LC, Shi S, Hébert JM. (2009). The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. J. Neurosci. 29: 14571–14580. PMID: 19923290, PMCID: PMC2826126.

Hébert JM, Fishell G. (2008). The genetics of telencephalon patterning: some assembly required. Nat. Rev. Neurosci. 9: 678–685. PMID: 19143049, PMCID: PMC2669317.

Fernandes M, Hébert JM. (2008). The ups and downs of holoprosencephaly, dorsal versus ventral patterning forces. Clin. Gen. 73: 413–423. PMID: 18394003.

Chang W, Lin Z, Kulessa H, Hébert J, Hogan BLM, Wu DK. (2008). Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genetics 4: e1000050. PMID: 18404215, PMCID: PMC2274953.

Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hébert JM, Jones K, Kessaris N, de Rouvroit CL, Richardson WD, O’Leary D, Goffinet AM, Tissir F. (2008). Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320: 946–949. PMID: 18487195, PMCID: PMC2746700.


Fernandes M, Gutin G, Alcorn H, McConnell SK, Hébert JM. (2007). Mutations in the BMP pathway in mice supports the existence of two molecular classes of holoprosencephaly. Development 134: 3789–3794. PMID: 17913790.

Hanashima C, Fernandes M, Hébert JM, Fishell G. (2007). The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J. Neurosc. 27: 11103–11111. PMID: 17928452.


Arnold JS, Werling U, Braunstein EM, Liao J, Nowotschin S, Edelmann W, Hébert JM, Morrow BE. (2006). Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 133: 977–987. PMID: 16452092.

Storm E, Garel S, Borello U, Hébert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JLR. (2006). Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133: 1831–1844. PMID: 16613831.

Tole S*, Gutin G*, Remedios R, Bhatnagar L, Hébert JM. (2006). Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev. Biol. 289: 141–151. PMID: 16309667. *co-first authors

Gutin G*, Fernandes M*, Pallazolo L, Paek H, Kai Y, Ornitz D, McConnell SK, Hébert JM. (2006). FGF acts independently of SHH to generate ventral telencephalic cells. Development 133: 2937–2946. PMID: 16818446. *co-first authors


Hébert JM. (2005). Unraveling the molecular pathways that regulate early telencephalon development. Curr. Top. in Dev. Biol. 69: 17–37. PMID: 16243595